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KMID : 0358419950380101958
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Korean Journal of Obstetrics and Gynecology
1995 Volume.38 No. 10 p.1958 ~ p.1966
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p53 Expression in Epithelial Ovarian Cancer: The Influence on the Prognosis and Celluar Proliferation
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정재돈
이주희/홍진기/이선경/김승보/이재현
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Abstract
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It has been recognized that abnormalities of tumor suppressor gene play a significant role in development of human cancer. One of the most common genetic alterations seen in human malignancies is inactivation of P53 tumor suppressor gene In
recent
studies many authors has reported that intranuclear accumulation of p53 suppressor gene is common finding of various types of human cancer and is closely correlated with poor prognosis.
We adapted p53 and PCNA(proliferating cell nuclear antigen) immunohistochemical staining to evaluate the prognostic significance of p53 expression in p53 expression in epithelial ovarian cancer and to compare the relationship between p53
expression
and
cellular proliferation.
We used paraffine embedded block of epithelial ovarian cancer from 38 patients treated at Kyung-Hee University between 1982~1992.
P53 expression was seen in 39.5%(15/38) of epithelial ovarian cancer, 8.3%(1/12) in borderline malignancy but not in normal ovary. Although p53 expression was lower in early stage ovarian cancer (stage I, II) than advanced stage and lower in
mucinous
cancer(26.7%) than other types of epithelial ovarian cancer, the ralationship were not statistically significant. There were no relationship between p53 expression and size of tumor disease free survial but significantly higher recurrence rate
was
seen
in p53 expression group.
The present study suggested that p53 expression could be utilized as a predictor of recurrence and showed that p53 expression was associated with inappropriate cellular growth but not with adverse outcome of epithelial ovarian cancer.
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KEYWORD
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